哮喘患者脂联素水平的变化及意义_《中国呼吸与危重监护杂志》

作者：

丁念昌 , 邓星奇 , 周玲 , 顾薇 , 李艳艳

上海市闵行区中心医院急诊科( 上海201199) 通信作者: 邓星奇, E-mail: dengchengsheng@ sina. com;

关键词：

哮喘脂联素肿瘤坏死因子α

DOI：

DOI: 10 . 7507 /1671 -6205 . 20130108

视频：

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目的测定哮喘急性发作期和哮喘缓解期患者脂联素水平, 探讨脂联素在哮喘发病机制中的作用。
方法收集2010 年10 月至2011 年9 月期间在上海市闵行区中心医院就诊的哮喘患者97 例, 其中急性发作期50 例, 缓解期47 例, 另选同期非吸烟健康体检者27 例作为对照。用ELISA法检测血清脂联素与肿瘤坏死因子α( TNF-α) 水平, 同时测定肺功能( FEV1% pred、RV% pred) , 分析脂联素水平和TNF-α、肺功能之间的相关性。应用SPSS 19. 0 软件进行统计学分析, 多组数据间比较采用单因素方差分析, 采用Pearson 相关分析进行相关性检验。
结果哮喘急性发作期组血清脂联素浓度[ ( 2. 46 ±1. 21) ng/mL] 低于缓解期组[ ( 3. 79 ±0. 96) ng/mL] 和健康对照组[ ( 9. 64 ±4. 88) ng/mL] ( P 均 lt;0. 01) , 哮喘缓解期组血浆脂联素浓度低于健康对照组( P lt; 0. 01) 。哮喘急性发作期组及缓解期组血清脂联素与TNF-α、RV% pred 呈负相关( P lt; 0. 01) , 与FEV1% pred 呈正相关( P lt;0. 01) 。
结论哮喘患者血清脂联素水平降低, 脂联素在哮喘中可能起保护作用。

引用本文： 丁念昌,邓星奇,周玲,顾薇,李艳艳. 哮喘患者脂联素水平的变化及意义. 中国呼吸与危重监护杂志, 2013, 12(5): 451-453. doi: DOI: 10 . 7507 /1671 -6205 . 20130108 复制

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2.	Wamer SM, Knight DA. Airway modeling and remodeling in the pathogenesis of asthma. Curr Opin Allergy Clin Immunol, 2008,8: 44-48.
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4.	Shore SA, Fredberg JJ. Obesity, smooth muscle, and airway hyperresponsiveness. J Allergy Clin Immunol, 2005, 115 : 925-927.
5.	Miller M, Cho JY, Pham A, et al. Adiponectin and functional adiponectin receptor 1 are expressed by airway epithelial cells in chronic obstructive pulmonary disease. J Immunol, 2009,182:684-691.
6.	谢娟, 邓星奇, 龙威, 等, 慢性阻塞性肺疾病患者血浆脂联素水平及其与白介素17 的相关性. 中国呼吸与危重监护杂志,2011, 10: 21 -24 .
7.	郭茂清, 朱述阳. 脂联素对气道平滑肌细胞增殖作用及一磷酸腺苷活化蛋白激酶活性的影响. 中国呼吸与危重监护杂志,2010, 9: 264 -267.
8.	Silvestri M, Bontempelli M, Giacomelll M, et al. High serum levels of tumour necrosls factor-alpha and interleukin-8 in severe asthma: markers of systemic inflammation. Clin Exp Allergy, 2006, 36: 1373-1381.
9.	Havel PJ. Control of energy homeostasis and insulin action by adipocyte hormones: leptin, acylation stimulating protein, and adiponectin. Curr Opin Lipidol, 2002, 13: 51 -59.
10.	Enqeli S, Feldpausch M, Gorzelniak K, et al. Association between adiponectin and mediators of inflammation in obese women.Diabetes, 2003, 52 : 942-947.
11.	James A. Airway remodeling in asthma. Curr Opin Pulm Med,2005, 11: 1-6.
12.	Shore SA, Terry RD, Flynt L, et al. Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice. J Allergy Clin Immunol, 2006, 118: 389 -395.
13.	Summer R, Little FF, Ouchi N, et al. Alveolar macrophage activation and an emphysema-like phenotype in adiponectindeficient mice. Am J Physiol Lung Cell Mol Physiol, 2008, 294 :L1035-L1042.

1. Scherer PE, Williams S , Fogilano M , et al. A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem,1995, 270: 26746-26749.
2. Wamer SM, Knight DA. Airway modeling and remodeling in the pathogenesis of asthma. Curr Opin Allergy Clin Immunol, 2008,8: 44-48.
3. 中华医学会呼吸病学分会哮喘学组. 支气管哮喘防治指南. 中华结核和呼吸杂志, 2008 , 31: 177-185.
4. Shore SA, Fredberg JJ. Obesity, smooth muscle, and airway hyperresponsiveness. J Allergy Clin Immunol, 2005, 115 : 925-927.
5. Miller M, Cho JY, Pham A, et al. Adiponectin and functional adiponectin receptor 1 are expressed by airway epithelial cells in chronic obstructive pulmonary disease. J Immunol, 2009,182:684-691.
6. 谢娟, 邓星奇, 龙威, 等, 慢性阻塞性肺疾病患者血浆脂联素水平及其与白介素17 的相关性. 中国呼吸与危重监护杂志,2011, 10: 21 -24 .
7. 郭茂清, 朱述阳. 脂联素对气道平滑肌细胞增殖作用及一磷酸腺苷活化蛋白激酶活性的影响. 中国呼吸与危重监护杂志,2010, 9: 264 -267.
8. Silvestri M, Bontempelli M, Giacomelll M, et al. High serum levels of tumour necrosls factor-alpha and interleukin-8 in severe asthma: markers of systemic inflammation. Clin Exp Allergy, 2006, 36: 1373-1381.
9. Havel PJ. Control of energy homeostasis and insulin action by adipocyte hormones: leptin, acylation stimulating protein, and adiponectin. Curr Opin Lipidol, 2002, 13: 51 -59.
10. Enqeli S, Feldpausch M, Gorzelniak K, et al. Association between adiponectin and mediators of inflammation in obese women.Diabetes, 2003, 52 : 942-947.
11. James A. Airway remodeling in asthma. Curr Opin Pulm Med,2005, 11: 1-6.
12. Shore SA, Terry RD, Flynt L, et al. Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice. J Allergy Clin Immunol, 2006, 118: 389 -395.
13. Summer R, Little FF, Ouchi N, et al. Alveolar macrophage activation and an emphysema-like phenotype in adiponectindeficient mice. Am J Physiol Lung Cell Mol Physiol, 2008, 294 :L1035-L1042.

《中国呼吸与危重监护杂志》

哮喘患者脂联素水平的变化及意义

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《中国呼吸与危重监护杂志》

哮喘患者脂联素水平的变化及意义

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